A system and method are provided for a high resolution radiation treatment system which provide for projecting a field of radiation energy at targeted patient tissue. The system uses a multi-leaf collimator, which is positioned such that a significant clearance is provided between the multi-leaf collimator and the isocenter plane where the targeted tissue is located. The leaves of the multi-leaf collimator are designed to provide for high step resolution in the projected radiation energy shape. Additionally, an embodiment of the system and method herein can provide for a high step resolution in the projected radiation energy shape, and for a dose calculation matrix which has matrix units which coincide with the high step resolution in the projected radiation shape.