President and Fellows of Harvard College;Massachusetts Eye & Ear Infirmary
发明人:
REMENSCHNEIDER, Aaron K.,KOZIN, Elliott,BLACK, Nicole,MCKENNA, Michael J.,LEE, Daniel J.,LEWIS, Jennifer,ROSOWSKI, John,KOLESKY, David,SKYLAR-SCOTT, Mark A.,VALENTINE, Alexander D.
申请号：
EP16769523
公开号：
EP3270821A4
申请日:
2016.03.21
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a plurality of spaces between the ribs filled or made with the first material, a different, second material, a combination of the first and a second materials, or a combination of a second material and one or more other different materials. The bilayer graft devices have two components or layers. One component, e.g., the under-lay graft device, can include a projection, and the second component, e.g., the overlay graft device, can include an opening that corresponds to the projection (or vice versa) so that the opening and the projection can secure the two layers together in a “lock and key” manner. This disclosure also features methods of making, using, and implanting the three-dimensional artificial tympanic membrane and bilayer graft devices.
