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Composition and Content of cake in suspension with carbostirilo derivative and Derivative of silicone Oil and / or Silicone Oil
专利权人:
LTD.;OTSUKA PHARMACEUTICAL CO.
发明人:
HIRAOKA SHOGO
申请号:
ARP110103020
公开号:
AR082494A1
申请日:
2011.08.19
申请国别(地区):
AR
年份:
2012
代理人:
摘要:
Claim 1: a method to prevent the particles of active ingredient Congregate in a suspension; suspension contains an active ingredient derived from Silicone Oil and / or Silicone oil in a dispersion medium; the active ingredient is at leastA member selected from the group consisting of Aripiprazole and a compound represented by Structural formula (1), the active ingredient is in the form of particles having an average Primary particle size of 0.1 mm or more,And less than 200 mm; The Method comprises mixing the active ingredient with the Derivative of silicone Oil and / or Silicone oil in a dispersion medium, in such a way that the Derivative of silicone Oil and / or Silicone Oil are contained in a quantity of between 0.001 and 0.2 Parts by weight relative to 100 parts by weight of the active ingredient content in the suspension.Claim 4: a suspension comprising an active ingredient derived from Silicone Oil and / or Silicone oil in a dispersion medium; the active ingredient is at leastA member selected from the group consisting of Aripiprazole and a compound represented by Structural formula (1) is the active ingredient in the form of particles having an average Primary particle size of 0.1 mm or more,And less than 200 mm, and where the Derivative of silicone Oil and / or Silicone Oil are contained in a quantity of between 0.001 and 0.2 parts by weight relative to 100 parts by weight of the active ingredient content in the suspension.Claim 7: a composition comprising an active ingredient and cake derived from Silicone Oil and / or Silicone Oil; the active ingredient is at leastA member selected from the group consisting of Aripiprazole and a compound represented by the following Structural formula (1) the active ingredient is in Particulate form and has an average particle size of 0.1 mm or greater, and less than 200 mm and where der Ivado Silicone Oil and / or Silicone oil is contained in an amount of between 0.001 and 0.2 parts by weight relative to 100 parts
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