Kyonsoo HONG;Makoto NISHIYAMA;Kazunobu TOGASHI;Melanie J. von Schimmelmann
发明人:
Kyonsoo HONG,Makoto NISHIYAMA,Kazunobu TOGASHI,Melanie J. von Schimmelmann
申请号：
US13465795
公开号：
US20120321594A1
申请日:
2012.05.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
One aspect of the present invention relates to a method of controlling axon or dendrite development in a neuronal cell population. This method involves providing a neuronal cell population and contacting the neuronal cell population with a modulator of R-type Ca2+ channel expression or activity in controlling the neuronal cell population to induce either axon or dendrite development. Another aspect of the present invention relates to a method of treating neuronal injury in a subject. This method involves selecting a subject with neuronal injury mediated by R-type Ca2+ channel expression or activity and administering to the selected subject an inhibitor of R-type Ca2+ channel expression or activity to induce neuronal axon development under conditions effective to treat the neuronal injury in the subject. Yet another aspect of the present invention relates to a method of screening for agents that modulate R-type Ca2+ channel expression or activity.
