Sanford Burnham Prebys Medical Discovery Institute
发明人:
Carl F. Ware,John R. Sedy
申请号：
US14916986
公开号：
US10759863B2
申请日:
2014.09.04
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relate to the discovery that BTLA, IL-7 and RORγt modulate the activity and expression of γδT cells. Specifically, the present invention provides methods of modulating γδT cell homeostasis and function by regulating expression of BTLA. The present invention further provides agents which modulate the activity and expression of BTLA, RORyt and IL-7 and methods for screening of such agents. The present invention also provides methods for treating autoimmune or inflammatory diseases using modulators of BTLA, RORyt and IL-7.
