Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases (NII KPSSZ)
发明人:
申请号：
EP14829254.3
公开号：
EP3025736B1
申请日:
2014.07.21
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
A method for the manufacture of biodegradable membranes for preventing adhesion formation followed open heart surgery is described herein. The manufacturing of biodegradable membranes is based on polymeric composition, comprised of copolymer of polyhydroxybutyrate / hydroxyvalerate (PHBV), poly (D, L-lactide) in the ratio of the dried powders of 3: 1, the resulting mixture is dissolved in chloroform to a concentration of 6-9% followed by thorough mixing for 2 hours and heating up to 35° C. The membrane is produced by electrostatic spinning (electrospinning), wherein biologically active substances from fibrinolytic agents or direct anticoagulants are embedded in the structure of the fiber.
