Allison Anne Byers Horner;Rosemary Girgis;Dina Rebecca McLain;Kristi Rae Bollinger;Frederic J. de Sauvage;Katherin E. Combs;Ling Ling Culbertson;Jaime-Jo Cunningham;Char;Joel Edwards;Leslie Jane Green
发明人:
Kristi Rae Bollinger,Katherin E. Combs,Jaime-Jo Cunningham,Ling Ling Culbertson,Frederic J. de Sauvage,Joel Edwards,Leslie Jane Green,Rosemary Girgis,Allison Anne Byers Horner,Dina Rebecca McLain,Char
申请号：
US13205917
公开号：
US20120005766A1
申请日:
2011.08.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders； cardiovascular, endothelial or angiogenic disorders； cyc abnormalities； immunological disorders； oncological disorders； bone metabolic abnormalities or disorders； lipid metabolic disorders； or developmental abnormalities.
