ALLEN, JENNIFER R,BOURBEAU, MATTHEW P,CHEN, NING,HU, ESSA,KUNZ, ROXANNE,RUMFELT, SHANNON
申请号：
NZ59250809
公开号：
NZ592508A
申请日:
2009.11.16
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
592508 Disclosed are pyrazine compounds of formula (I) where the substituents are as disclosed in the specification. The compounds are useful as phosphodiesterase 10 (PDE10) inhibitors which mediate diseases such as schizophrenia, bipolar disorder, and obsessive-compulsive disorder. Also disclosed are pharmaceutical compositions comprising the compounds and use of the compounds for manufacturing a medicament. Examples of compounds of formula (I) are: 1-(4-(3-(6-(benzo[d]thiazol-2-ylamino)pyridin-3-yloxy)pyrazin-2-yl)piperidin-1-yl)ethanone (R)-4-(3-(4-(benzo[d]thiazol-2-ylamino)phenoxy)pyrazin-2-yl)-6-methylpiperazin-2-one and (rac)-trans-3-(3-(4-(benzo[d]thiazol-2-ylamino)phenoxy)pyrazin-2-yl)cyclohexanol.
