COMPOSES UTILISES POUR L'INHIBITION DU RECAPTAGE DE 5-HYDROXYTRYPTAMINE ET DE NOREPINEPHRINE OU POUR LE TRAITEMENT DE TROUBLES DE DEPRESSION, METHODES DE PREPARATION DESDITS COMPOSES ET UTILISATIONS CONNEXES

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专利权人:

LI, YOUXIN;SHANDONG LUYE PHARMACEUTICAL CO., LTD.

发明人:

ZHANG, LUPING

申请号：

CA2612413

公开号：

CA2612413C

申请日:

2006.06.16

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

The present invention discloses compounds of formula (I), their opticalisomersor pharmaceutically acceptable salts thereof, their preparation and usesthereof,wherein the definitions of R1, R2, R3 and R4 are shown in the description.Thesecompounds are optical isomers or racemic mixtures. After these compounds areuptaken, they are metabolically transformated in vivo into 1-[2-dimethylamino-1--(4-hydroxyphenyl)-ethyl]-cyclohexanol that has neuropharmacologicalactivity,by interrupting reuptake of 5-hydroxytryptamine (5-HT) and/or norepinephrine(NA) , which is used for treating diseases associated with central nervesystem,such as depression, etc.(see formula I)

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