Simon James Anthony Grove,Ronald Palin,Ashvinkumar Dhirubhai Mistry,John Kinnaird Ferguson MacLean
申请号：
US12611468
公开号：
US08188123B2
申请日:
2009.11.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula Iwherein R1 is (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, or halo(C1-4)alkyloxy R2 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen R3 is H, (C1-4)alkyl or halo(C1-4)alkyl R4 is H, (C1-4)alkyl or halo(C1-4)alkyl R5 is H, (C1-4)alkyl or halo-(C1-4)-alkyl or R4 and R5, when bonded to the same carbon atom, can together with the carbon atom form a spiro(C3-6)cycloalkyl group, optionally substituted with halogen R6 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these (pyrrolidin-2-yl)phenyl derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.
