COMPOSITIONS ET METHODES DE TRAITEMENT DE DEFAUTS DANS UN TISSU CARTILAGINEUX AVASCULAIRE PAR ADMINISTRATION DIRECTE D'UN OU PLUSIEURS METABOLITES DE SIMVASTATINE
Controlled release hydrogel formulations of one or more simvastatin metabolites 3'-hydroxy simvastatin (hSV), 6'-exomethylene simvastatin (eSV), 3',5'-dihydrodiol simvastatin, 3', 5'-dihydrodiol simvastatin (dSV), simvastatin-beta-hydroxy acid (SVA), and methods for the treatment of patients suffering from injured or degenerating substantially avascular cartilaginous tissue.