A segmentation selection system includes a transducer (14) configured to transmit and receive imaging energy for imaging a subject. A signal processor (26) is configured to process imaging data received to generate processed image data. A segmentation module (50) is configured to generate a plurality of segmentations of the subject based on features or combinations of features of the imaging data and/or the processed image data. A selection mechanism (52) is configured to select one of the plurality of segmentations that best meets a criterion for performing a task.