<；P>；PROBLEM TO BE SOLVED: To find, from natural products, substances having MMP-1 inhibitory activity, MMP-2 inhibitory activity, estrogen-like activity, profilaggrin production-promoting activity, filaggrin production-promoting activity and cAMP phosphodiesterase inhibitory activity, respectively, and based on the above findings, to provide an MMP-1 inhibitor, an MMP-2 inhibitor, an estrogen-like action agent, a profilaggrin production promoter, a filaggrin production promoter, an antiobese agent and a cAMP phosphodiesterase inhibitor, with the above substances as active ingredients, respectively. <；P>；SOLUTION: The MMP-1 inhibitor, the MMP-2 inhibitor, the estrogen-like action agent, the profilaggrin production promoter, the filaggrin production promoter, the antiobese agent and the cAMP phosphodiesterase inhibitor are obtained by including an extract from Osmanthus fragrans var. aurantiacus and/or acteoside, respectively. <；P>；COPYRIGHT: (C)2009,JPO&INPIT
