<;P>;PROBLEM TO BE SOLVED: To provide an agent that is safer to living bodies than a conventional component for inhibiting CYP1 expression and sufficiently inhibits cytochrome P450-1B1 (CYP1B1) expression. <;P>;SOLUTION: A loquat extract has been found to have an excellent inhibitory action on CYP1B1 expression. By the knowledge, the agent that comprises the loquat extract as an active ingredient and inhibits CYP1B1 expression is provided. <;P>;COPYRIGHT: (C)2011,JPO&INPIT