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Glycoside derivatives and their uses for the treatment of diabetes
专利权人:
Novartis AG
发明人:
BEBERNITZ, Gregory Raymond
申请号:
ES12719083
公开号:
ES2621007T3
申请日:
2012.04.12
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound represented by structural formula (1): ** Formula ** or a pharmaceutically acceptable salt thereof, in which: A is selected from the group consisting of "n: ** Formula ** You see hydrogen, halo or - OR'b; R ', R'a and R'b are independently selected from the group consisting of hydrogen, Cl-S alkyl, CS-lo-C'-4-alkyl, -C (O) -C6-10 aryl , and -C (O) -C alkyl, -6; R2 and R2a, for each occurrence, are independently selected from the group consisting of halo, hydroxy, CH alkyl, and CH alkoxy; R 3 is halo, hydroxy, CH alkyl, halo-Cl-S alkyl, C 3-10 cycloalkyl, CH alkoxy, or C-halo-alkoxy; R 4 is selected from the group consisting of: ** Formula ** R 5 is an amino acid side chain that is a side chain amino acid that occurs naturally selected from the group consisting of the side chain of glycine, alanine, cysteine, asparagine, glutamine, glutamic acid, arginine, aspartic acid, histidine, lysine, isoleucine, leucine, m ethionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine and valine; or an unusual amino acid side chain selected from the group consisting of the 3,5-dibromotyrosine, 3,5-diiodothyrosine, gem-dimethyl-glycine, hydroxylysine, amino-butyric acid, hydroxy-proline, lantionin, thyroxine side chain , ornithine and citrulline; R6 is a CH alkyl, C3-10 carbocyclyl, C3 carbocyclyl-C1-4alkyl, 3-10 membered heterocyclyl, (3-10 membered heterocyclyl) -C1-alkyl, C6-10 aryl, C6 aryl -l0-Cl-4 alkyl, 5-10 membered heteroaryl, or (5-10 membered heteroaryl) -C 1-4 alkyl; R7, for each occurrence, is independently hydrogen, CH alkyl, C3-10 carbocyclyl, C3-lo-C4-alkyl, 3-10 membered heterocyclyl, (3-10 membered heterocyclyl) -C1-4 alkyl, aryl C6-10, C6-10-aryl-Cl-4 alkyl, 5-10 membered heteroaryl, or (5-10 membered heteroaryl) -C 1-4 alkyl; nesO, 1, 2 or 3; and q is O, 1 or 2.Compuesto representado por la fórmula estructural (1):**Fórmula** o una sal farmacéutica mente aceptable del mismo, en el que: A se selecciona del grupo que consiste e"n:**Fórmula*
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