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ЛИОФИЛИЗИРОВАННЫЕ ЛЕКАРСТВЕННЫЕ НАНОСУСПЕНЗИИ
专利权人:
ЯНССЕН ФАРМАЦЕВТИКА НВ (BE)
发明人:
ИНГЕЛБРЕХТ Сабин Карин Катрин (BE),ГИЗЕЛЕР Хеннинг (DE),БЕРОВСКИ Якоб Андреас (DE)
申请号:
RU2013150803/15
公开号:
RU2013150803A
申请日:
2012.04.13
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. Lyophilized nanosuspension comprising drug and a steric stabilizer which is a solid at room temperature.2. Lyophilized nanosuspension according to claim. 1, wherein the steric stabilizer is a crystalline solid at room temperature.3. Lyophilized nanosuspension according to claim. 1, wherein the steric stabilizer is an amorphous solid at room temperature.4. Lyophilized nanosuspension according to claim. 1, wherein the steric stabilizer is selected from a polymer or surfactant veschestva.5. Lyophilized nanosuspension according to claim. 4, wherein the steric stabilizer is a surfactant veschestvo.6. Lyophilized nanosuspension according to claim. 5, wherein the surfactant is a poloksamer.7. Lyophilized nanosuspension according to claim. 6, wherein the poloxamer is poloxamer 338.8. Lyophilized nanosuspension according to claim. 1 further comprising krioprotektor.9. Lyophilized nanosuspension according to claim. 8, wherein the cryoprotectant is selected from polyvinylpyrrolidone, sucrose, tregalozy.10. Lyophilized nanosuspension according to claim. 9, wherein the cryoprotectant is a polivinilpirrolidon.11. Lyophilized nanosuspension according to claim. 1-10, wherein the drug is sparingly soluble, very sparingly soluble or almost insoluble drugs sredstvom.12. Lyophilized nanosuspension according to claim. 1-10, wherein the medicament is 4 - [[4 - [[4- (2-cyanoethenyl) -2,6-dimethylphenyl] amino] -2-pyrimidinyl] amino] benzonitrile, or a stereoisomeric form thereof or a pharmaceutically sol.13 acceptable. L Lyophilized nanosuspension according to claim. 1 further comprising krioprotektor.9. Lyophilized nanosuspension according to claim. 8, wherein the cryoprotectant is selected from polyvinylpyrrolidone, sucrose, tregalozy.10. Lyophilized nanosuspension according to claim. 9, wherein the cryoprotectant is a polivinilpirrolidon.11. Lyophilized nanosuspension according to claim. 1-10, wherein the drug is sparingly soluble, very sparingly soluble or almost insoluble drugs sr
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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