#$%^&*AU2016100802A420160707.pdf#####Enhanced Trans-Dermal or Trans-Mucosal Delivery Of high First-Pass Medications, Flavours and Sensations Using Terpene Micelle Nanosomes Abstract The Invention consists of a self-emulsifying liquid formulation to be used as an excipient to deliver pharmaceutically, organoleptically or biologically active agents via the skin or mucous tissues. Trans-dermal and trans-mucosal penetration of the Invention is enhanced by the spontaneous formation of terpene micelle nanosomes upon contact with water, sweat or saliva. These nanosomes may encapsulate active ingredients, and facilitate their extracellular and intracellular delivery and systemic circulation, resulting in reduced losses of certain active ingredients due to first-pass metabolism. Lower effective dosage rates may be achieved for certain active ingredients such as sensations, flavours, scents, and high first-pass medications.
