THE UNIVERSITY OF MANCHESTER;ST. GEORGE'S HOSPITAL MEDICAL SCHOOL
发明人:
ROBINSON, CLIVE,ZHANG, JIHUI,GARROD, DAVID RONALD,PERRIOR, TREVOR ROBERT,NEWTON, GARY KARL,JENKINS, KERRY,BEEVERS, REBEKAH ELISABETH,MAYOR, MERIEL RUTH,STEWART, MARK RICHARD
申请号：
ES11701854
公开号：
ES2544732T3
申请日:
2011.01.21
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound selected from compounds of the following formula, and pharmaceutically acceptable salts, hydrates and solvates thereof: wherein: ** Formula ** -R1 is independently -H or -R1A； -R1A is saturated aliphatic C1-6 alkyl, and is optionally substituted with one or more substituents -RX1； -R2 is -H； -R3 is independently -H or -R3A； -R3A is saturated aliphatic C1-3 alkyl； -R4 is -R4A； -R4A is -Me； -R5 is -H； -R6 is -H or -R6A； -R6A is saturated aliphatic C1-3 alkyl； -R7 is -H, -R7A or -R7B； -R7A is saturated aliphatic C1-6 alkyl； -R7B is independently -L7B1, -R7BB or -R7BB； -L7B1- is saturated aliphatic C1-3 alkylene； -R7BB is independently -R7BB1, -R7BB2, -R7BB3 or -R7BB4； -R7BB1 is independently phenyl or naphthyl, and is optionally substituted with one or more substituents -RX3； -R7BB2 is C5-10 heteroaryl, and is optionally substituted with one or more substituents -RX3； -R7BB3 is C3-7 cycloalkyl, and is optionally substituted with one or more substituents -RX2, or is optionally fused to a benzene ring that is optionally substituted with one or more substituents - RX2； -R7BB4 is saturated bridged C5-10 cycloalkyl, and is optionally substituted with one or more substituents - RX2； -R8 is -H； -R9 is independently -H or -R9A； -R9A is saturated aliphatic C1-4 alkyl； -R10 is independently -R10A, -R10B, -R10C or -R10D； -R10A is independently phenyl or naphthyl, and is optionally substituted with one or more substituents -RX3； -R10B is C5-10 heteroaryl, and is optionally substituted with one or more substituents -RX3； -R10C is saturated C3-7 cycloalkyl, and is optionally substituted with one or more substituents -RX2； -R10D is non-aromatic C3-10 heterocyclyl, and is optionally substituted with one or more substituents -RX2； or -R9 and -R10, taken together with the nitrogen atom and the carbon atom to which they are attached respectively, form a non-aromatic C5-7 heterocyclic lactam ring, which is optionally substituted with one or more substituents -RX2, or which is o
