HOWARD, Philip Wilson,GREGSON, Stephen John,MASTERSON, Luke
申请号：
ES09740185
公开号：
ES2557283T3
申请日:
2009.10.16
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound with the formula I: ** Formula ** in which: R2 is of formula II: ** Formula ** in which A is a C5-7 aryl group, X is selected from the group comprising: OH, SH, CO2H, COH, N>； = C>； = O, NHRN, where RN is selected from the group comprising H and C1-4 alkyl, and (OC2H4) mOCH3, where m is 1 to 3, and either: (i) Q1 is a single link, and Q2 is selected from a single link and -Z- (CH2) n-, where Z is selected from a single link, O, S and NH and n is 1 to 3； or (ii) Q1 is -CH>； = CH- and Q2 is a single link； R12 is a C5-10 aryl group, optionally substituted with one or more substituents selected from the group comprising: halo, nitro, cyano, C1-7 alkoxy, C5-20 aryloxy, C3-20 heterocyclyloxy, C1-7 alkyl, heterocyclyl C3-7 and C1-3 bisoxy alkylene, wherein the C1-7 alkoxy group may be substituted with an amino group, and if the C3-7 heterocyclyl group is a C6 heterocyclyl group containing nitrogen, it may be substituted with a group C1-4 alkyl； R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR ', nitro, Me3Sn and halo； where R and R 'are independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups； R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NHRR ', nitro, Me3Sn and halo； either: (a) R10 is H and R11 is OH, ORA, where RA is C1-4 alkyl； (b) R10 and R11 form a double nitrogen-carbon bond between the nitrogen and carbon atoms to which they are attached； or (c) R10 is H and R11 is SOzM, where z is 2 or 3 and M is a pharmaceutically acceptable monovalent cation； R "is a C3-12 alkylene group, whose chain can be interrupted by one or more heteroatoms, and / or aromatic rings； Y and Y 'are selected from O, S or NH； R6', R7 ', R9' are selected of the same groups as R6, R7 and R9, respectively, and R10 'and R11' are the same as R10 and R11, where, if R11 and R11 'are SOzM, M may represent a pharmaceutically acceptable divalent cation, and where the The term "alkyl" includes alkenyl, alky
