Methods for identifying host clones, methods for producing antibody mixtures, methods for producing recombinant host cells, transgenic non-human animals or plants, antibody mixtures, pharmaceutical compositions, and use of antibody mixtures
The invention provides methods for producing mixtures of antibodies from a single host cell clone. Thereto, a nucleic acid sequence encoding a common light chain, and nucleic acid sequences encoding two different heavy chains are expressed in a recombinant host cell. The antibodies in mixtures according to the invention comprise two different heavy chains capable of pairing to a common light chain, thereby forming functional antigen binding domains. Mixtures of antibodies, and use of these mixtures in a variety of field, are also provided by the invention.
