HOUTZAGER, ERWIN,PINTO, RUI DANIEL,LOGTENBERG, TON,THROSBY, MARK
申请号：
DK09075279
公开号：
DK2147594T3
申请日:
2009.06.29
申请国别(地区):
DK
年份:
2014
代理人:
摘要：
The invention provides transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. The invention further provides methods for producing an immunoglobulin from the transgenic, non-human animal.
