LUAN, YEN-TUNG,WANG, WENGE,NYBERG, GREGG,GOMES, JOSE, MANUEL,DRAPEAU, DENIS,CARDOZA, TERRY
申请号：
DK09733052
公开号：
DK2310523T3
申请日:
2009.04.16
申请国别(地区):
DK
年份:
2015
代理人:
摘要：
Methods and processes for improved recombinant protein production are provided. The methods are useful for production of growth factors, particularly those of the TGF-&bgr； superfamily, including bone morphogenetic proteins (BMPs), such as BMP-2. Suitable host cells are cultured in media where iron is present at a concentration of at least 2.25 &mu；M and if pyridoxal is present, it makes up less than 55% of the molar concentration of vitamin B6 in the media.
