Cardoza, Terry,Luan, Yen-Tung,Nyberg, Gregg,Drapeau, Denis,Wang, Wenge,Gomes, Jose Manuel
申请号：
AU2009236187
公开号：
AU2009236187B2
申请日:
2009.04.16
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Methods and processes for improved recombinant protein production are provided. The methods are useful for production of growth factors, particularly those of the TGF-β superfamily, including bone morphogenetic proteins (BMPs), such as BMP-2. Suitable host cells are cultured in media where iron is present at a concentration of at least 2.25 μM and if pyridoxal is present, it makes up less than 55 % of the molar concentration of vitamin B6 in the media.
