Use of Apoptosis-specific eIF-5A siRNA to Down Regulate Expression of Proinflammatory Cytokines to Treat Sepsis

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专利权人:

Charles A. Dinarello;John E. Thompson

发明人:

John E. Thompson,Charles A. Dinarello

申请号：

US13487951

公开号：

US20130253032A1

申请日:

2012.06.04

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for down regulating pro-inflammatory cytokines in a mammal by administering siRNA against eIF-5A1 to the mammal to treat/prevent sepsis and/or hemorrhagic shock.

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