Dihidroisoquinolinas derived compounds or their salts as inhibitors of the activity of antiapoptotic Proteins BCL XL； Pharmaceutical composition that is useful for the treatment of bladder cancer, Breast, Brain, Bone Marrow, esophageal, colorectal, ovarian, Leuc Chronic Lymphocytic EMIA, or cancer of the Spleen, among others.
SOUERS, ANDREW,WANG, LE,DOHERTY, GEORGE,WANG, XILU,TAO, ZHI-FU,BRUNKO, MILAN,KUNZER, AARON R.,WENDT, MICHAEL D.,SONG, XIAOHONG,FREY, ROBIN,HANSEN, TODD M.,SULLIVAN, GERARD,JUDD, ANDREW
申请号：
CL2014000922
公开号：
CL2014000922A1
申请日:
2014.04.11
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and compounds (I) for use in the methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.<；p>；<；strong>；COMPUESTOS DERIVADOS DE DIHIDROISOQUINOLINAS SUSTITUIDAS, INHIBIDORES DE LA ACTIVIDAD DE LAS PROTEÍ；NAS ANTIAPOPTÓ；TICAS BCL-XL； COMPOSICIÓ；N FARMACÉ；UTICA； Y USO PARA EL TRATAMIENTO DE CÁ；NCER DE VEJIGA, CEREBRO, MAMAS, MÉ；DULA Ó；SEA, COLORRECTAL, ESÓ；FAGO, OVARIO, LEUCEMIA LINFOCÍ；TICA CRÓ；NICA O CÁ；NCER ； DE BAZO, ENTRE OTRAS<；/strong>；<；/p>；
