PROBLEM TO BE SOLVED: To provide the enhanced utilization of a physiologically active substance, such as ferulic acid, having an anti-oxidative action in vivo with an increased solubility of the physiologically active substance.SOLUTION: According to the present invention, a rice bran enzyme-treated product is obtained by subjecting a rice bran of pigmented rice, such as purple rice, to enzyme treatment with a cellulase enzyme agent. Furthermore, an extract, preferably a water extract, of the rice bran enzyme-treated product is obtained. The rice bran enzyme-treated product or the water extract thereof is used as a dissolution aid or an absorption promoter of a physiologically active substance. By ingesting a pharmaceutical composition or food composition produced using the rice bran enzyme-treated product or the extract, the bioavailability of the physiologically active substance contained therein is enhanced.SELECTED DRAWING: Figure 4COPYRIGHT: (C)2017,JPO&INPIT【課題】 抗酸化作用を有するフェルラ酸のような生理活性物質の溶解性を高め、生体内における生理活性物質の利用性を高める。【解決手段】 紫黒米のような有色素米の米糠をセルラーゼ酵素剤などで酵素処理を行い米糠の酵素処理物を得る。さらには当該米糠酵素処理物の抽出物、好ましくは水抽出物を得る。当該米糠酵素処理物又は水抽出物を、生理活性物質の溶解補助剤又は吸収促進剤として用いる。当該米糠酵素処理物や抽出物を用いて製造された医薬組成物や食品組成物を摂取することで、それらに含まれる生理活性物質の生物学的利用能が高められる。【選択図】図4
