PROBLEM TO BE SOLVED: To provide a method of increasing the effect of an activated-potentiated antibody comprising an activated-potentiated antibody to an endogenous biological molecule, and an activated-potentiated antibody to endothelial NO-synthase.SOLUTION: By using an activated-potentiated antibody to an endogenous biological molecule, such as an antibody to prostate specific antigen or an antibody to insulin receptor in combination with an activated-potentiated antibody to NO-synthase, a method of increasing the effect of an activated-potentiated antibody to an endogenous biological molecule, and a pharmaceutical composition comprising an activated-potentiated antibody to an endogenous biological molecule, and an activated-potentiated antibody to NO synthase.SELECTED DRAWING: None【課題】内在生体分子に対する活性化増強型抗体と、内皮ＮＯ合成酵素に対する活性化増強型抗体とを含む、活性化増強型抗体の効果を増大する方法の提供。【解決手段】前立腺特異的抗原に対する抗体、又はインスリン受容体に対する抗体等の内在生体分子に対する活性化増強型抗体と、ＮＯ合成酵素に対する活性化増強型抗体とを組み合わせて用いることによって、内在生体分子に対する活性化増強型抗体の効果を増大させる方法、及び内在生体分子に対する活性化増強型抗体と、ＮＯ合成酵素に対する活性化増強型抗体とを含む医薬組成物。【選択図】なし
