Wolchok, Jedd D.,Avogadri, Francesca,Olmsted, Robert A.,Maughan, Maureen
申请号：
AU2015249175
公开号：
AU2015249175A1
申请日:
2015.10.30
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2015249175A120151210.pdf#####ABSTRACT The immune response to melanoma cells and tumors can be induced or significantly increased by administering to a subject a pharmaceutical composition comprising alphavirus particles, especially Venezuelan equine encephalitis virus replicon particles, which express the melanoma 5 antigen dopachrome tautomerase (DCT, TRP2) in cells of the subject, with the result of tumor regression and/or inhibition of metastasis of a melanoma subject, or a decreased risk of the occurrence or recurrence of melanoma and/or decreased severity of melanoma in a subject not suffering from melanoma at the time of administration. The pharmaceutical composition described herein can be used in conjunction with other therapeutic agents, it can be 10 administered on more than one occasion and it can be combined with administrations of other compositions such as protein or other immunogentic compositions, and/or adjuvants, with beneficial effects to the human or animal subject to which it has been administered.
