A ca6 antigen-specific cytotoxic conjugate and methods of using the same

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专利权人:

IMMUNOGEN INC.

发明人:

PAYNE GILLIAN,CHUN PHILIP,TAVARES DANIEL J

申请号：

NZ61279604

公开号：

NZ612796A

申请日:

2004.07.21

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Disclosed is an antibody or epitope-binding fragment thereof comprising a heavy chain variable region or fragment thereof and a light chain variable region or fragment thereof； wherein said heavy chain variable region or fragment thereof comprises three sequential complementarity-determining regions having amino acids SYNMH, YIYPGNGATNYNQKFQG and GDSVPFAY of SEQ ID NO:11； wherein said light chain variable region or fragment thereof comprises three sequential complementarity-determining regions having amino acids SAHSSVSFMH, STSSLAS, QQRSSFPLT of SEQ ID NO:8； wherein said antibody binds a CA6 glycotope, and wherein the sequences are as defined in the complete specification.

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