A syringe pump configured to mechanically align a force sensor with an axis of a plunger of a syringe for a purpose of minimizing force measurement inaccuracies. The syringe pump includes a syringe pump housing that is configured to receive at least a portion of said syringe, wherein the syringe is selected from a plurality of syringes of different dimensions. A plunger retainer mechanism is pivotably coupled to the syringe pump housing and is configured to retain said plunger of said syringe. The plunger retainer mechanism pivots relative to the syringe pump housing based on a sensed dimension of the plunger to align a force sensor coupled to the plunger retainer mechanism with the axis of the plunger； and a syringe drive mechanism is operably coupled to the syringe pump housing and configured to shift the plunger relative to the portion of the syringe received by the syringe pump housing.
