An apparatus and method for syringe plunger positioning employing an actuator for linear advancement and retraction of the support member along a predetermined axis, and a plurality of arm members each interconnected to the support for movement therewith, and each moveable relative to the support member in corresponding different directions towards and away from the predetermined axis. The actuator may be operable to advance the support member to an advanced position for movement of the arm members from an open position in the different corresponding directions towards the predetermined axis to a closed position, and to retract the support member from the advanced position so that distal end portions of the arm members engage an inside surface of a plunger button of syringe having a barrel located in a fixed, axially aligned position on the predetermined axis. The apparatus and method may be employed in conjunction with syringe plunger positioning (e.g. for filling operations) that accommodates a wide variety of syringe plunger button configurations.
