Hyunhee Ahn,Young Min Ju,Anthony Atala,Sang Jin Lee
申请号：
US14518352
公开号：
US10092679B2
申请日:
2014.10.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Vascular scaffolds and methods of fabricating the same are disclosed for tissue engineering of vascular constructs. By combining electrospun matrices with cell sheet technologies, vascular constructs with more mature cell layers can be obtained for reconstruction of blood vessels, heart valves and the like. A engineered smooth muscle cell sheet, wrapped around an electrospun vascular scaffold, is able to provide a mature SMC layer that expresses strong cell-to-cell junction markers and contractile proteins. In addition, preconditioning of the cell sheet covered vascular scaffold maintained cell viability and infiltration into the scaffold.
