Nazila KAMALY,Tammy Louise KALBER,Gavin David KENNY,Maya THANOU,Andrew David MILLER,Jimmy BELL
申请号：
US15463964
公开号：
US20170348440A1
申请日:
2017.03.20
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides novel liposomes comprising Gd.DOTA.DSA (gadolinium (III) 2-{4,7-bis-carboxymethyl-10-[(N,N-distearylamidomethyl-N′-amido-methyl]-1,4,7,10-tetra-azacyclododec-1-yl}-acetic acid), characterised in that said liposome further comprises a neutral, fully saturated phospholipid component (e.g. DSPC (1,2-distearoyl-sn-glycero-3-phospocholine]), which are of particular use in the preparation of magnetic resonance contrast agents for enhancing a magnetic resonance image of tumours in a mammal.
