Nazila Kamaly,Tammy Louise Kalber,Gavin David Kenny,Maya Thanou,Andrew David Miller,Jimmy Bell
申请号：
US13511126
公开号：
US20130129636A1
申请日:
2010.11.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides novel liposomes comprising Gd.DOTA.DSA (gadolinium(III)2-{4,7-bis-carboxymethyl-10-[(N,N-distearylamidomethyl-N′-amido-methyl]-1,4,7,10-tetra-azacyclododec-1-yl}-acetic acid), characterised in that said liposome further comprises a neutral, fully saturated phospholipid component (e.g. DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine]), which are of particular use in the preparation of magnetic resonance contrast agents for enhancing a magnetic resonance image of tumours in a mammal.
