The invention provides isolated fully human monoclonal anti-HRV antibodies, as well as method of making and using these antibodies. Anti-HRV antibodies of the invention prevent or treat subjects having HRV-infections, and related diseases, including, but not limited to, the common cold, nasopharyngitis, croup, pneumonia, bronchiolitis, asthma, chronic obstructive pulmonary disease (COPD), sinusitis, bacterial superinfection, and cystic fibrosis.Linvention concerne des anticorps monoclonaux entièrement humains anti-RVH isolés, ainsi que des méthodes de production et dutilisation desdits anticorps. Les anticorps anti-RVH de linvention permettent de prévenir ou de traiter les sujets atteints dinfections par le RVH, ainsi que les maladies associées, dont, notamment, le rhume, la rhinopharyngite, la diphtérie laryngienne, la pneumonie, la bronchiolite, lasthme, la bronchopneumopathie chronique obstructive (BPCO), la sinusite, la surinfection bactérienne et la mucoviscidose.