The invention relates to a three- dimensionally printed pharmaceutical dosage form comprising a first pharmacologically active ingredient and a second pharmacologically active ingredient; wherein the relative weight ratio of the first pharmacologically active ingredient to the second pharmacologically active ingredient in the pharmaceutical dosage form is within the range of from 10,000 : 1 to 1 : 1. The invention also relates to a process for the preparation of such pharmaceutical dosage form by three- dimensional printing, preferably by fused deposition modeling.