An injection device with a gearing arrangement providing a gearing ratio between axial movement of an injection button and axial movement of a piston rod. The injection device comprises a dose setting member being operable to set a dose by rotating the dose setting member relatively to a housing, about a rotational axis. During setting of a dose the gearing arrangement is prevented from rotating along with the dose setting member about the rotational axis. Thereby the space which it is necessary to accommodate to the gearing arrangement inside the housing is reduced. This provides the possibility of using this space for other purposes, such as additional electronic components, designing the injection device in a manner which is appropriate for other purposes, e.g. with a relatively flat cross section, or reducing the overall size of the injection device. According to one aspect of the invention, the gearing arrangement comprises at least one gear wheel having a rotational axis which is non-parallel to, e.g. substantially perpendicular to, the rotational axis of the dose setting member. According to another aspect of the invention, the gearing arrangement comprises a driving spindle being provided with a threaded portion having a first pitch, and the piston rod is provided with a threaded portion having a second pitch. The gearing is provided by the threaded portions.
