PROBLEM TO BE SOLVED: To provide a therapeutic agent for depression based on an action mechanism different from a conventional tricyclic antidepressant or selective serotonin reuptake inhibitor which is known to produce various side effects.SOLUTION: This antidepressant contains a histone deacetylase 6 inhibitor illustrated by a formula as an active ingredient.COPYRIGHT: (C)2012,JPO&INPIT【課題】さまざまな副作用を伴うことが知られている従来の三環系抗うつ薬や選択的セロトニン再取り込み阻害剤とは異なる作用機序に基づく、うつ病に対する治療薬の提供。【解決手段】下記式で例示されるヒストン脱アセチル化酵素6阻害剤を有効成分として含有する抗うつ薬。【選択図】なし