Consejo Superior De Investigaciones Cientificas (CSIC);Consiglio Nazionale Delle Ricerche
发明人:
Jose Manuel Delgado Lopez,Jaime Gomez Morales,Raquel Fernandez Penas,Michele Iafisco,Anna Tampieri,Silvia Panseri
申请号：
US15327817
公开号：
US20170209491A1
申请日:
2015.07.21
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Process for obtaining fluoride-doped citrate-coated amorphous calcium phosphate nanoparticles. This material has applications in biomedicine due to its biodegradability and bioactivity； it also promotes cell adhesion and osteogeneration. In dentistry, it may be used in toothpastes, mouthwashes, chewing gums, gels and fluoride varnishes as a remineralising agent of dentine and enamel. It is based on two solutions formed by calcium chloride and sodium citrate on the one hand, and by sodium monohydrogenophosphate and sodium carbonate with a fluoride compound on the other, which are mixed at room temperature. The process is eco-efficient and eco-friendly, as it does not leave any acid residue； it consists of a single stage and it is the first time that an amorphous calcium phosphate coated with citrate and doped with fluoride, which enhances its remineralising action, is obtained.
