INSTITUTO NACIONAL DE PSIQUIATRÍA RAMÓN DE LA FUENTE MUÑIZ
发明人:
BENITO ANTÓN PALMA,PHILIPPE LEFF GELMAN
申请号：
MX2011010866
公开号：
MX346303B
申请日:
2004.07.07
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
The invention relates to the structure, preparation methods and chemical composition of two structural formulations of bivalent vaccines against addiction to morphine/heroin (mor-phinc-6-hcmisuccinyl-UDC-TrCS-tctanic toxoid and 3-0-carboxymcthylmor-phine-RDC-TPCS-telanic toxoid), which are suitable for use in human vaccination and which can induce the synthesis of polyclonal antibodies against said addictive opiate and the structural analogue thereof (heroin), with the repeated in vivo administration of same in an active vaccination scheme in preclinical phase studies in relation to the rodent animal model. The invention also relates to the active vaccination paradigm with the aforementioned immunogens, which can induce a humoral immune response which has high liters of specific antibodies and which is consolidated in long-term memory against said two drugs. In addition, the invention outlines the way in which the aforementioned chemical immunogen compositions can provide effective im munoprotection against addiction to morphine and the highly-addictive structural congener thereof (heroin) In the pharmacological model relating to addictive intravenous self-administration of said two opiates in rodents. Finally, the Invention relates to the therapeutic Implications of the possible later use of said immunoconjugates in active vaccination schemes for the treatment of addiction to said two drugs in humans.La presente invención se refiere a el diseño estructural, métodos de preparación y composición química de dos formulaciones estructurales de vacunas bivalentes contra la adicción a morfina-heroína (morfina-6-hemiscuccinil-EDC-TFCS-toxoide tetánico y 3-O-carboximetlmorfina-EDC-TFCS-toxoide tetánico), adecuados para su empleo en la vacunación en el humano, los cuales son capaces de inducir la síntesis de anticuerpos policlonales contra este opiáceo adictivo y contra su análogo estructural la heroína, a través de su administración repetida in vivo, en un esquema de vacuna
