ZIELINSKI, Joseph Lawrence,VRETTOS, John,JI, Qin,PATEL, Subash
申请号：
TN2012000310
公开号：
TN2012000310A1
申请日:
2012.06.20
申请国别(地区):
TN
年份:
2013
代理人:
摘要：
The present invention provides a tablet comprising a hydroxypropylcellulose and an active ingredient selected from compounds of Formula (I) and salts thereof: wherein R1 represents CF3, CHF2, CH2F, CH3CHF-, CH3CF2-, ethyl or iso-propyl and R2 represents alkyl substituted by one or more substituents, the substituents being selected from the group consisting of halogen, nitro, cyano, acyl, hydroxy, oxo (=0), alkoxy, cycloalkoxy, acyloxy, alkoxycarbonyloxy, amino, alkylamino, dialkylamino, formyl, acylamino, alkoxycarbonylamino or R2 represents heterocyclylalkyl substituted by one or more substituents, the substituents being selected from the group consisting of halogen, nitro, cyano, hydroxy, alkoxy, alkylcarbonyloxy, alkoxycarbonyloxy, amino, alkylamino, dialkylamino, alkoxycarbonylamino, or R2 represents phenyl substituted by one or more substituents, the substituents being selected from the group consisting of cyano, hydroxy, alkanediyl, alkenediyl, alkoxy, hydroxyalkyl, formyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonyloxy, alkoxycarbonyloxy, amino, alkylamino, dialkylamino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxycarbonylamino, or R2 represents heterocyclyl optionally substituted by one or more substituents, the substituents being selected from the group consisting of halogen, hydroxy, amino, nitro, cyano, alkyl, hydroxalkyl, alkoxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, acyl, alkoxy, acyloxy, alkoxycarbonyloxy, amino, alkylamino, dialkylamino, acylamino, alkoxycarbonylamino and whereby the heterocycle is bound to the phenyl ring by a carbon-atom. The invention also provides a process for preparing the above tablet.
