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Methods of reducing T cell-mediated immune responses with multimeric P-selectin and/or E-selectin compounds
专利权人:
Rong-Hwa Lin
发明人:
Rong-Hwa Lin,Chung Nan Chang
申请号:
US12562515
公开号:
US08628775B2
申请日:
2009.09.18
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Multimeric compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The multimeric compounds and methods of the invention can be used to control unwanted T cell- or NK cell-mediated immune responses in conditions such as inflammatory diseases, autoimmune diseases, transplant rejection, and allergic diseases.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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