BRIGHAM YOUNG UNIVERSITY;THE SCRIPPS RESEARCH INSTITUTE;THE UNIVERSITY OF CHICAGO
发明人:
TEYTON, LUC,BENDELAC, ALBERT,SAVAGE, PAUL
申请号：
DK06733921
公开号：
DK1848813T3
申请日:
2006.01.26
申请国别(地区):
DK
年份:
2013
代理人:
摘要：
Disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, methods of improving vaccine efficacy, and methods of treating an infection. Also disclosed are methods of promoting tumor rejection, treating cancer, modulating autoimmunity and inhibiting allergen-induced hypersensitivity in subjects. The methods include contacting an NKT cell with a bacterial glycolipid complexed with a CD1 molecule to activate the NKT cell. The bacterial glycolipid may be derived from a member of the Class Alphaproteobacteria.
