PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
发明人:
CHUNG, Hae Young,정해영,MOON, Hyung Ryong,문형룡,MOON, Kyoung Mi,문경미,PARK, Yun Jung,박윤정,KIM, Nam-Deuk,김남득,PARK, Ji Young,박지영,KIM, Hye Rim,김혜림,KIM, Cheol Min,김철민,JEONG, Ji Won,정지원
申请号：
KRKR2015/007655
公开号：
WO2016/032127A3
申请日:
2015.07.23
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
The present invention relates to novel compounds having antioxidant and anti-inflammatory effects of inhibiting the activity of macrophages due to competition with LPS for binding to TLR4, and a medical use thereof. The compounds, according to the present invention, have antioxidant and anti-inflammatory activities, and thus can be used for geriatric disease prevention or inflammation treatment. In addition, the compounds compete with LPS for binding to TLR4-MD2, in particular, thereby being used as a pharmaceutical composition useful in the prevention and treatment of sepsis, metabolic diseases, or cardiovascular diseases, or as a health food, by means of the competition with LPS for binding to TLR4-MD2.La présente invention concerne de nouveaux composés présentant des effets antioxydants et anti-inflammatoires dinhibition de lactivité des macrophages en raison de la concurrence avec LPS pour se lier à TLR4. Linvention porte également sur leur utilisation médicale. Les composés de linvention présentent des activités antioxydantes et anti-inflammatoires, et peuvent donc être utilisés pour la prévention dune maladie gériatrique ou le traitement de linflammation. En outre, les composés concurrencent LPS pour se lier à TLR4-MD2, en particulier, étant ainsi utilisés en tant que composition pharmaceutique utile dans la prévention et le traitement de la septicémie, des maladies métaboliques ou des maladies cardio-vasculaires, ou comme aliment de santé, en raison de la concurrence avec LPS pour se lier au récepteur TLR4-MD2.본 발명은 TLR4에 LPS와의 경쟁적 결합을 통하여 대식세포의 활성을 억제하는 항산화, 항염증의 효과를 갖는 신규화합물 및 이의 의학적 용도에 관한 것으로, 본 발명에 따른 화합물들은 항산화 및 항염증 활성을 지니므로 노인성 질병의 예방 또는 염증 치료에 유용하게 사용될 수 있으며, 또한 TLR4-MD2에 LPS와 경쟁적 binding 함으로써 특히, LPS와 경쟁적인 결합을 통하여 패혈증, 대사성 질환 또는 심혈관계 질환을 예방하고 치료하는데 유용한 약학조성물 또는 건강식품으로 사용될 수 있다.
