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Emulsion mit mindestens einem Retinoid und Benzoylperoxid
专利权人:
Galderma Research & Development
发明人:
MALLARD, CLAIRE,LOUIS, FABIENNE,WILLCOX, NATHALIE
申请号:
EP12153664.3
公开号:
EP2460561A1
申请日:
2007.12.21
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
A composition (A), containing at least one retinoid (I) and benzoyl peroxide (II) in dispersed form, is in the form of an emulsion. An independent claim is included for the preparation of (A), by: (A) mixing (I) with wetting agent(s) and wetting surfactant(s) in water, to give a first active phase (1); (B) mixing (II) with wetting agent(s) and wetting surfactant(s) in water, to give a second active phase (2); (C) dissolving gelling agents and optionally chelating agents, preservatives and other non-heat sensitive hydrophilic additives in warm water to give a homogeneous aqueous phase; (D) homogeneously mixing emulsifiers, oils and/or solid lipids and optionally preservatives and other non-heat sensitive lipophilic additives under heating and stirring to give a homogeneous lipid phase; (E) adding the lipid phase to the aqueous phase to give an emulsion; (F) introducing the active phases (1) and (2); (G) optionally neutralizing to the desired pH; and (H) optionally adding heat-sensitive additives. ACTIVITY : Dermatological; Antiseborrheic; Antiinflammatory; Antipruritic; Antipsoriatic; Antirheumatic; Virucide; Vulnerary; Antiulcer; Fungicide; Antibacterial. MECHANISM OF ACTION : RAR and/or RXR receptor ligand; Cell differentiation and/or proliferation modulator; Free radical source.L'invention se rapporte à une composition sous forme d'émulsion comprenant, dans un milieu physiologiquement acceptable, au moins un rétinoïde et du péroxyde de benzoyle dispersé, à son procédé de préparation et à son utilisation en cosmétique et en dermatologie.
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