Compositions and methods for treating inflammation and autoimmune diseases

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专利权人:

ザ ジョンズ ホプキンス ユニバーシティー

发明人:

チェン， リーピン,チェン, リーピン

申请号：

JP2009544267

公开号：

JP5481199B2

申请日:

2007.12.27

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

Compositions containing soluble B7-H4 (sH4) antagonists in an amount effective to reduce, inhibit, or mitigate an inflammatory response in an individual and methods for the treatment or prophylaxis of inflammatory disorders and autoimmune diseases or disorders are provided. Soluble H4 has been discovered to interfere with B7-H4 activity including B7-H4's activity as an inhibitor of T cell immunity. Thus, interference of sH4 biological activity is an effective method to restore B7-H4 activity and thereby provide an effective method for treating inflammatory diseases or disorders including autoimmune diseases or disorders.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/