John Sigurd Svendsen;Istvan Marko;Morten Bøhmer Strøm;Merete Linchausen Skar;Wenche Stensen;Øystein Rekdal;Bengt Erik Haug
发明人:
John Sigurd Svendsen,Bengt Erik Haug,Istvan Marko,Øystein Rekdal,Merete Linchausen Skar,Wenche Stensen,Morten Bøhmer Strøm
申请号：
US13239662
公开号：
US20120108520A1
申请日:
2011.09.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having at least one more cationic than anionic moiety, in the manufacture of a medicament for destabilising microbial cell membranes and the use as a membrane acting antimicrobial agent of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto a super bulky and lipophilic group comprising at least 9 non-hydrogen atoms and having at least two more cationic than anionic moieties and to methods of treatment involving such molecules, in particular peptides including peptide derivatives, and peptidomimetics.
