HISTOSONICS, INC.;THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人:
Jonathan M. CANNATA,Timothy L. HALL,Adam D. MAXWELL,Dejan TEOFILOVIC
申请号：
US16410821
公开号：
US20190275353A1
申请日:
2019.05.13
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods and devices for producing cavitation in tissue are provided. In one embodiment, a shock scattering method of Histotripsy therapy comprises delivering an initiation pressure waveform from an ultrasound therapy transducer into tissue, the initiation pressure waveform being configured to produce at least one bubble in the tissue, delivering a scattering pressure waveform from the ultrasound therapy transducer into the at least one bubble within a life-cycle of the at least one bubble, and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. The scattering pressure waveform can be delivered during the life-cycle of the at least one bubble. In some embodiments, the scattering pressure waveform is delivered within 5 μs to 1 s of the initiation pressure waveform. Systems for performing shock scattering Histotripsy therapy are also discussed.
