Markus HÖRER,Stefan KOCHANEK,Caroline HAUSER,Alexandra KRÜGER-HAAG
申请号：
US16755283
公开号：
US20200239859A1
申请日:
2018.10.12
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention generally concerns the production of defective Adenovirus helper viruses for producing a recombinant adeno-associated virus (rAAV), wherein the Adenovirus helper virus contains at least one mutation selected from (a) an inactivating mutation in the transcription unit coding for the L4-100K protein； (b) an inactivating mutation in the transcription unit coding for the L1-52/55K protein； (c) an inactivating mutation in the transcription unit coding for the preterminal protein (pTP)； (d) a mutation in the L4-100K protein in order to render it temperature-sensitive (ts)； (e) a mutation in the hexon protein in order to render it temperature-sensitive (ts)； and/or (f) a mutation in the L4-00K protein and a mutation in the hexon protein in order to render it temperature-sensitive (ts).
