ПРОИЗВОДНЫЕ 6-БЕНЗИЛФЕНИЛ-2-СУЛЬФУРТЕТРАГИДРОПИРАН-3,4,5-ТРИОЛА В КАЧЕСТВЕ ИНГИБИТОРОВ НАТРИЙ-ГЛЮКОЗНЫХ КОТРАНСПОРТЕРОВ 1 И 2 ДЛЯ ПРИМЕНЕНИЯ У БОЛЬНЫХ ДИАБЕТОМ
БРАУН Филип Мэнтон (US),ФРЕЙМАН Джоэл Филип (US),ПОУЭЛЛ Дэвид Рид (US)
申请号：
RU2012141893/15
公开号：
RU2012141893A
申请日:
2011.03.01
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A dose of 300 mg / day or less (eg, 250, 200, 150, 100 or 50 mg / day or less) of the dual inhibitor NGT1 / 2 (sodium glucose co-transporter 1/2) of the formula or a pharmaceutically acceptable salt thereof for use in improving the cardiovascular or metabolic health of diabetic patients or pre-diabetic patients taking at this time DPP-4 (dipeptidyl peptidase-4) inhibitor, wherein: each R independently defines hydrogen, alkyl, aryl or heterocycle each R independently represents hydrogen, hydroxyl, amino , alkyl, aryl, cyano, halogen, heteroalkyl, het nitro, C≡CR, OR, SR, SOR, SOR, C (O) R, COR, COH, CON (R) (R), CONH (R), CONH, NHC (O) R, or NHSOR alkyl, aryl, cyano, halogen, heteroalkyl, heterocycle, nitro, C≡CR, OR, SR, SOR, SOR, C (O) R, COR, COH, CON (R) (R), CONH (R), CONH, NHC (O) R, or NHSOR each R independently defines alkyl, aryl or heterocycle, m is 1-4, n is 1 -3, p is 0-2, and where each alkyl, aryl, heteroalkyl or heterocycle is optionally substituted with one or more of: alkoxy, amino, cyano, halo, hydroxyl or nitro. The dose for use according to claim 1, wherein the improvement means lowering the fasting plasma glucose level of the patient more than about 50, 55 or 60 mg / dL. The dose for use according to claim 1, wherein the improvement means lowering the hemoglobin A1c level in the patient by more than about 1.0, 1.1 or 1.2%. The dose for use according to claim 1, wherein the improvement means a decrease in the fructosamine level in the blood plasma of the patient by more than about 30, 40 or 50 μmol / L. The dose for use according to claim 1, wherein the improvement means lowering the blood pressure of the patient.1. Доза в 300 мг/день или менее (например, 250, 200, 150, 100 или 50 мг/день или менее) двойственного ингибитора НГТ1/2 (натрий-глюкозный котранспортер 1/2) формулыили его фармацевтически приемлемой соли для применения в улучшении сердечно-сосудистого или метаболического здоровья больных диабетом или пред-диабетических больных, принима
